منابع مشابه
Mechanisms governing the control of mRNA translation.
The translation of cellular mRNA to protein is a tightly controlled process often deregulated in diseases such as cancer. Furthering our understanding of mRNA structural elements and the intracellular proteins and signaling pathways that affect protein expression is crucial in the development of new therapies. In this review, we discuss the current state-of-the-art of detecting and determining ...
متن کاملControl of mRNA Translation in ALS Proteinopathy
Cells robustly reprogram gene expression during stress generated by protein misfolding and aggregation. In this condition, cells assemble the bulk of mRNAs into translationally silent stress granules (SGs), while they sustain the translation of specific mRNAs coding for proteins that are needed to overcome cellular stress. Alterations of this process are deeply associated to neurodegeneration. ...
متن کاملQuality Control of mRNA Function
be coupled to each other as well, a feat also thought to Most eukaryotic cellular proteins are generated by transbe orchestrated by the CTD as an additional measure lation of mRNAs that have successfully passed a number of QC. Efficient capping enhances both splicing and 39 of steps to insure their quality. Transcripts that fail to end formation, and efficient 39 end formation enhances pass sel...
متن کاملmRNA quality control goes transcriptional
Eukaryotic mRNAs are extensively processed to generate functional transcripts, which are 5' capped, spliced and 3' polyadenylated. Accumulation of unprocessed (aberrant) mRNAs can be deleterious for the cell, hence processing fidelity is closely monitored by QC (quality control) mechanisms that identify erroneous transcripts and initiate their selective removal. Nucleases including Xrn2/Rat1 an...
متن کاملLinks between mRNA splicing, mRNA quality control, and intellectual disability.
In recent years, the impairment of RNA binding proteins that play key roles in the post-transcriptional regulation of gene expression has been linked to numerous neurological diseases. These RNA binding proteins perform critical mRNA processing steps in the nucleus, including splicing, polyadenylation, and export. In many cases, these RNA binding proteins are ubiquitously expressed raising key ...
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ژورنال
عنوان ژورنال: Nature Structural & Molecular Biology
سال: 2012
ISSN: 1545-9993,1545-9985
DOI: 10.1038/nsmb.2301